Scientific Papers

Aging

Computational and digital analyses in the INSPIRE mouse cohort to define sex-specific functional determinants of biological aging Major oscillations in spontaneous home-cage activity in C57BL/6 mice housed under constant conditions

Autoimmune Disease

Role of Human Mesenchymal Stem Cells and Derived Extracellular Vesicles in Reducing Sensory Neuron Hyperexcitability and Pain Behaviors in Murine Osteoarthritis Mouse Models of Osteoarthritis: A Summary of Models and Outcomes Assessment Conditional Deletions of Hdc Confirm Roles of Histamine in Anaphylaxis and Circadian Activity but Not in Autoimmune Encephalomyelitis

Cardiovascular

Indoleamine 2,3-Dioxygenase Deletion to Modulate Kynurenine Pathway and to Prevent Brain Injury After Cardiac Arrest in Mice

Chronobiology

Evaluation of the Digital Ventilated Cage® system for circadian phenotyping Effects of Cage Position and Light Transmission on Home Cage Activity and Circadian Entrainment in Mice

Epilepsy/Seizure

Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability

Infectious Disease

Downregulation of hypocretin/orexin after H1N1 Pandemrix vaccination of adolescent mice

Metabolism

Gut microbiota from persons with attention-deficit/hyperactivity disorder affects the brain in mice

Neuroscience

Bradykinesia and postural instability in a model of prodromal synucleinopathy with α-synuclein aggregation initiated in the gigantocellular nuclei Abnormal cytoskeletal remodeling but normal neuronal excitability in a mouse model of the recurrent developmental and epileptic encephalopathy-susceptibility KCNB1-p.R312H variant Accurate locomotor activity profiles of group-housed mice derived from home cage monitoring data Experimental sickness reduces hypocretin receptor 1 expression in the lateral hypothalamus and ventral tegmental area of female mice Non-invasive detection of narcolepsy type I phenotypical features and disease progression by continuous home-cage monitoring of activity in two mouse models: the HCRT-KO and DTA model Microglial Nogo delays recovery following traumatic brain injury in mice The Preventive Effect of Exercise and Oral Branched-Chain Amino Acid Supplementation on Obesity-Induced Brain Changes in Ldlr-/-.Leiden Mice Excessive rest time during active phase is reliably detected in a mouse model of myotonic dystrophy type 1 using home cage monitoring Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle Doxycycline rescues recognition memory and circadian motor rhythmicity but does not prevent terminal disease in fatal familial insomnia mice The Impact of Voluntary Exercise on Stroke Recovery Early-adolescent antibiotic exposure results in mitochondrial and behavioral deficits in adult male mice Chronic fluoxetine or ketamine treatment differentially affects brain energy homeostasis which is not exacerbated in mice with trait suboptimal mitochondrial function A Non-invasive Digital Biomarker for the Detection of Rest Disturbances in the SOD1G93A Mouse Model of ALS Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr(-/-) .Leiden mice Automated Analysis of Stroke Mouse Trajectory Data With Traja Hydroxytyrosol, the Major Phenolic Compound of Olive Oil, as an Acute Therapeutic Strategy after Ischemic Stroke Food and water restriction lead to differential learning behaviors in a head-fixed two-choice visual discrimination task for mice

Oncology

Detection of aberrant locomotor activity in a mouse model of lung cancer via home cage monitoring Activity in Group-Housed Home Cages of Mice as a Novel Preclinical Biomarker in Oncology Studies

Phenotyping

Evaluation of the Digital Ventilated Cage® system for circadian phenotyping Data repurposing from digital home cage monitoring enlightens new perspectives on mouse motor behaviour and reduction principle Phenotyping spontaneous locomotor activity in inbred and outbred mouse strains by using Digital Ventilated Cages Towards large scale automated cage monitoring - Diurnal rhythm and impact of interventions on in-cage activity of C57BL/6J mice recorded 24/7 with a non-disrupting capacitive-based technique

Review

Editorial: Home Cage-Based Phenotyping in Rodents: Innovation, Standardization, Reproducibility and Translational Improvement Emerging Role of Translational Digital Biomarkers Within Home Cage Monitoring Technologies in Preclinical Drug Discovery and Development Three Pillars of Automated Home-Cage Phenotyping of Mice: Novel Findings, Refinement, and Reproducibility Based on Literature and Experience

Surgical Recovery

Continuous locomotor activity monitoring to assess animal welfare following intracranial surgery in mice Unraveling the link: locomotor activity exerts a dual role in predicting Achilles tendon healing and boosting regeneration in mice

Validation

A multicentre study on spontaneous in-cage activity and micro-environmental conditions of IVC housed C57BL/6J mice during consecutive cycles of bi-weekly cage-change Traja: A Python toolbox for animal trajectory analysis Non-intrusive high throughput automated data collection from the home cage Long term study on the effects of housing C57BL/6NCrl mice in cages equipped with wireless technology generating extremely low intensity electromagnetic fields The effect of exposure to low frequency electromagnetic fields (EMF) as an integral part of the housing system on anxiety-related behavior, cognition and welfare in two strains of laboratory mouse

Welfare

Using home-cage monitoring to determine the impact of timed mating on male mouse welfare Automated Home-Cage Monitoring During Acute Experimental Colitis in Mice Effect of Environmental Enrichment on Aggression in BALB/cJ and BALB/cByJ Mice Monitored by Using an Automated System
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