DVC® Technology: no definite effects on C57BL/6NCrl mice

DVC® Technology: no definite effects on C57BL/6NCrl mice
// 1 May 2019

An interesting article titled “Long-Term Study on the Effects of Housing C57BL/6NCrl Mice in Cages Equipped With Wireless Technology Generating Extremely Low-Intensity Electromagnetic Fields” has been recently published (May 2019) on Toxicology Pathology.

The Author, Camilla Recordati -DVM, PhD, Dipl ECVP Veterinary Pathologist from Mouse and Animal Pathology Laboratory (MAPLab), Fondazione Unimi, Milano, Italy - is a very important Opinion Leader in LAS.

Dr Recordati introduced this the starting  from the evaluation of how the recent development of mouse cages equipped with monitoring wireless technology raised questions on the potential effects on animals induced by electromagnetic fields (EMFs) generated by electronic boards positioned underneath the cages. Her objective was  to characterize the EMF produced by digitally ventilated cages (DVC) and perform a clinicopathological study on mice maintained in DVC for up to 1 year. The EMFs were measured in empty individually ventilated cages (IVCs) and DVC®s. Male (n ¼ 160) and female (n ¼ 160) C57BL/6NCrl mice were randomly housed in IVCs and DVC®s in a single rack, 4 mice per cage. Body weight and food and water consumption were recorded at 14-day intervals. At sacrifice (days 60, 120, 180, and 365), body and testes weight was measured, and necropsy, hematology, bone marrow cytology, histology, and immunohistochemistry for cleaved-caspase 3 on the testes were performed. Digitally ventilated cages produced extremely low-intensity electric fields ranging from 5 Hz to 3 GHz. No exposure-related clinical signs and mortality occurred. Occasional statistical differences in body weight, food and water consumption, hematology, bone marrow, and histopathology were recorded, but considered without biological or clinical relevance.

The conclusion of the study is that long-term maintenance in DVC has no definite effects on C57BL/6NCrl mice.

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